Simple relations describing the resultant moments of inertia forces of the first and second order for all sixty possible configurations of the crankshaft in two-stroke four-cylinder engine have been derived in the paper. A comparative analysis of the crankshafts with different arrangements of cranks have been carried out with respect to the resultant moments of the first and second order inertia forces. The comparison has been carried out for two values of the crank throw to connecting rod length ratio, namely l = 0.3 and l = 0.5. The outcomes of the comparative analysis indicate that irrespective of the l value, within the range of its values having practical meanings, the arrangement of cranks 1-5-3-4-2-6 is the best. As a result of 50% balancing of the moment of the first order inertia forces the differences between various configurations of the crankshaft are significantly reduced and configuration 1-4-2-6-3-5 equals with respect to balancing with the commonly used configuration 1-5-3-4-2-6.