The power and efficiency of a two-stroke engine strongly depends on the efficiency of the scavenging process which consists in re-moving the rest of the exhaust gases from the cylinder and filling it with a fresh charge. The quality of the charge exchange process is significantly influenced by the construction of the intake system. The paper presents a zero-dimensional model of the aircraft two-stroke opposed-piston diesel engine with two variants of the intake system: with a mechanical compressor and a turbocharger connected in series with a mechanical compressor. Simulation studies of the developed cases were carried out in the AVL BOOST software. For the defined engine operating points, its performance was compared for different designs of the intake system. It was confirmed that the use of a turbocharger with a mechanical compressor extends the range of operating at high altitudes.