In this paper methodology for simulation of the Rotating Detonation Engines in ANSYS Fluent is developed. The overall approach relies on a 2D geometry, global reaction models of the homogeneous kerosene-air mixture, and appropriate boundary and initial conditions. It leads to development and steady propagation of the detonation wave in a periodic channel. The wave structure and basic parameters are analyzed and compared to the data in the literature and an ideal Chapman-Jouguet detonation. The trends of the detonation speed are analyzed for range of equivalence ratios, mixture temperatures and pressures, mesh resolution and combustion models. The software is capable of simulation of complex phenomena occurring in the detonation wave. A cellular structure visible in real detonations can be predicted by CFD, although its scale differs due to simplifications employed. The study shows that this methodology can be used for analysis of propulsion systems operating on detonative combustion. It also indicates its limitations and areas for improvements. ANSYS Fluent flexibility and user-friendly interface combined with this methodology help the user concentrate on R&D instead of coding.